Gene information
Official symbol HDAC4
Official full name histone deacetylase 4
Gene type protein-coding gene
Chromosome2q37.3
Alias symbolKIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4
Previous symbolBDMR
Gene familyHistone deacetylases, class IIA; MicroRNA protein coding host genes
Resources
Entrez Gene 9759
HGNC HGNC:14063
Ensembl ENSG00000068024
Vega OTTHUMG00000133344
UCSC uc002vyk.4
GO terms: 42 records
GO Description Category LogP Number of genes Detail
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003300 cardiac muscle hypertrophy GO Biological Processes -10.9367469 14 More
GO:0005667 transcription regulator complex GO Cellular Components -7.37095162 26 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0006110 regulation of glycolytic process GO Biological Processes -6.41532756 12 More
GO:0006140 regulation of nucleotide metabolic process GO Biological Processes -7.41911571 18 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010677 negative regulation of cellular carbohydrate metabolic process GO Biological Processes -4.04738042 9 More
GO:0010830 regulation of myotube differentiation GO Biological Processes -3.96920305 9 More
GO:0014896 muscle hypertrophy GO Biological Processes -12.7837947 16 More
GO:0014897 striated muscle hypertrophy GO Biological Processes -10.7141263 14 More
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO Molecular Functions -6.05306731 14 More
GO:0017053 transcription repressor complex GO Cellular Components -4.12949610 12 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043433 negative regulation of DNA-binding transcription factor activity GO Biological Processes -10.6964949 32 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043470 regulation of carbohydrate catabolic process GO Biological Processes -8.06132628 15 More
GO:0043502 regulation of muscle adaptation GO Biological Processes -16.8828965 29 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045912 negative regulation of carbohydrate metabolic process GO Biological Processes -5.15495164 11 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051148 negative regulation of muscle cell differentiation GO Biological Processes -3.93077688 11 More
GO:0051153 regulation of striated muscle cell differentiation GO Biological Processes -11.0877013 23 More
GO:0051154 negative regulation of striated muscle cell differentiation GO Biological Processes -2.96833359 7 More
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding GO Molecular Functions -8.00802452 40 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062014 negative regulation of small molecule metabolic process GO Biological Processes -11.3582124 24 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1900542 regulation of purine nucleotide metabolic process GO Biological Processes -7.57719972 18 More
GO:1903578 regulation of ATP metabolic process GO Biological Processes -8.20286273 19 More
GO:1903579 negative regulation of ATP metabolic process GO Biological Processes -4.61361828 8 More
Drug-Gene interaction
view
Related drugs: 39 records
Drug name Interaction type Source PMID View
7-ethyl-10-hydroxycamptothecin DTC 23622981 view
abexinostat inhibitor TALC view
an-9 inhibitor TALC view
apicidin DTC 1970584617956988 view
ar-42 TdgClinicalTrial view
belinostat inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialChemblInteractions 25937017 view
butanoic acid DTC 19053749 view
butyrylhydroxamic acid DTC 21874153 view
chembl117487 DTC 17566732 view
chembl1650245 DTC 24044874 view
chembl324053 DTC 16921367 view
cudc-101 inhibitor TALCTdgClinicalTrialChemblInteractions view
dacinostat inhibitor DTC 17956988 view
daunorubicin DTC 22260166 view
depakote inhibitor TALC view
entinostat inhibitor DTCChemblInteractions 199667891838123820491440 view
fimepinostat inhibitor ChemblInteractions view
givinostat inhibitor TALCTdgClinicalTrial view
hinokitiol DTC view
largazole DTC 214203022520378220491440 view
mocetinostat DTCTdgClinicalTrial 2382948326287310 view
panobinostat inhibitor TALCMyCancerGenomeTdgClinicalTrial view
panobinostat lactate inhibitor ChemblInteractions view
phenylbutanoic acid DTC 24044874 view
phenylbutyrylhydroxamic acid DTC 21874153 view
pracinostat TdgClinicalTrial view
psammaplin a DTC 25884112 view
quisinostat inhibitor TTD view
resminostat TdgClinicalTrial view
romidepsin inhibitor MyCancerGenomeTdgClinicalTrialChemblInteractions 21587264 view
scriptaid inhibitor DTC 19966789 view
spiruchostatin c DTC 21967146 view
suberohydroxamic acid DTC 16921367 view
tacedinaline inhibitor DTCChemblInteractions 18692397 view
temozolomide PharmGKB 24444404 view
trichostatin DTC 21055848169213671996678919385600 view
ursolic acid DTC 19534471 view
valproic acid DTC 182948441692136725304896 view
vorinostat inhibitor TALCDTCMyCancerGenome 193441751996678926211462236229812226016618381238204914402154858219084294 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr2:239420657 hypermethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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